Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to understand how an antibiotic, rifampin, may change the blood
levels of another antibiotic, daptomycin, in the body. In addition, the effect of
polymorphisms in P-glycoprotein (a protein involved in the removal of daptomycin from the
body) on the blood levels of daptomycin will be evaluated. The hypotheses are that rifampin
will decrease the blood levels of daptomycin and that the effect will be greater for certain
P-glycoprotein polymorphisms.