Influence of Sirolimus and MMF on Vascular Function and Markers of Cellular Function in Renal Transplant Recipients
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
Chronic transplant nephropathy and cardiovascular death are the main reasons for loss of
transplanted organs after kidney transplantation.
Vascular changes, induced by hypertension and/or immunological processes, determine long time
transplant survival.
It will be tested whether the withdrawal of calcineurininhibitors will improve the vessel
wall function in renal transplant patients. It is supposed that this immunosuppressive
regimen reduces the activation of endothelial cells with important impact on arteriosclerosis
and therefore on patient and transplant survival.