Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis.

• Status: Unknown status
• Trial end date: 2020-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Treatment of smoker patients with AgP is considered a challenge to periodontists. To date, only one controlled clinical study (De Genaro Modanese et al., 2016) evaluated the effect of full mouth ultrasonic debridment (FMUD) on smokers with aggressive periodontitis. Its results showed significant improvements in clinical parameters (plaque index PI, bleeding on probing- BoP and probing depth-PD), and immunologic (reductions in interleukin 6- IL-6, tumor necrosis factor- α TNF-α levels), although the results were more favorable for non-smoking patients. Antimicrobials associated to mechanical therapy has been extensively studied (Hafajee et al., 2003, Heitz-Mayfield, 2006). The association of Amoxicillin and Metronidazole have had good clinical and microbiological results in randomized clinical trials in the treatment of AgP (Casarin et al., 2012, Sgolastra et al., 2012, Keestra et al., 2015).

Thus, this study investigates clinical, microbiological and immunological influence of smoking in the periodontal debridement associated to Amoxiciclin and Metronidazole of young individuals with pronounced periodontal destruction, compared with non-smokers individuals.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Campinas, Brazil
• Treatments: Amoxicillin; Metronidazole

Criteria

Inclusion Criteria:

• diagnosis of generalized aggressive periodontitis, according to the American Academy of Periodontology-AAP, 1999;

• presence of at least 15 teeth;

• presence of at least 6 teeth containing 6 deep sites (≥ 7 mm), which are not located in bifurcation areas and

• present less than 20% of plaque index (PI) and bleeding on probing (BoP).

Exclusion Criteria:

• presence of periapical or pulpar alteration;

• presence of systemic alteration or use of medications (6 months prior to the study) that may influence the response to periodontal treatment;

• pregnant and lactating women;

• performing periodontal treatment including subgingival instrumentation in the 6 weeks preceding the study;

• teeth with bifurcation involvement;

• teeth with marked mobility;

• oral pathology;

• history of allergy to any component of the study, and

• previous periodontal surgery in the region of interest.