Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Polyposis

• Status: Unknown status
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether sulindac and VSL#3 - inulin, either combined or alone, are effective in treating or preventing adenoma development in the ileal anal pouch in patients with familial adenomatous polyposis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Collaborator: Dutch Cancer Society
• Treatments: Sulindac

Criteria

Inclusion Criteria:

• Clinically or genetically proven familial adenomatous polyposis

• Restorative proctocolectomy with ileal pouch anal anastomosis

Exclusion Criteria:

• Chronic or acute renal or hepatic disease

• History of oesophageal, gastric or duodenal ulcers

• Known hypersensitivity to sulindac

• Daily use during the last three months of:

• Aspirin

• Non-Steroidal Anti-Inflammatory Agents

• Probiotics