Overview

Influence of the Autonomic Nervous System in Response to Exercise in Hypertensive Individuals

Status:
Recruiting

Trial end date:
2021-12-23

Target enrollment:
0

Participant gender:
All

Summary

Systemic arterial hypertension (SAH) has a direct association with endothelial dysfunction and major cardiovascular events. Evidence points to possible benefits of aerobic training in the endothelial function analyzed by the flow mediated dilation technique (flow mediated dilatation - FMD) in individuals with SAH. However, little is known about the influence of the autonomic nervous system (ANS) on the results of brachial artery FMD after different types of acute exercise in individuals with SAH. Thus, the objective of the research is to analyze the influence of the ANS on the FMD of the brachial artery of individuals with SAH after a session of aerobic (EA), resistance (ER) and combined (EC) exercise. For this, thirty-nine hypertensive individuals aged 35 to 55 years will be recruited and will be randomized to 2 sessions of AS, ER or EC. Also, within each modality, they will be randomized to α1-adrenergic block (Doxazosin 0.05 mg / kg-1) or placebo. The FMD will be performed by ultrasound 10 minutes before, as well as 10, 40 and 70 minutes after the exercise sessions and the autonomic control will be monitored (Finometer) for 10 minutes before each FMD. Arterial stiffness will also be analyzed, using the pulse wave velocity (PWV) by the Complior Analyzer. It is expected to demonstrate with this research the influence of the ANS on the FMD of the brachial artery in individuals with SAH in different physical exercises. This knowledge contributes to a better training prescription in this population.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Instituto de Cardiologia do Rio Grande do Sul

Treatments:

Adrenergic Agents
Doxazosin

Criteria

Inclusion Criteria:

- Clinical diagnosis of systemic arterial hypertension;

- Must be able to reality physical exercise.

Exclusion Criteria:

- Diabetes mellitus;

- Chronic renal failure;

- Body mass index ≥ 35kg/m2;

- Coronary artery disease;

- Heart failure;

- Use of beta-blocker;

- Uso of alpha-blocker;

- Smoker;

- Menopause (woman).