Inhalative Sedation in ICU With Sevoflurane Via Anaesthetic Conserving Device Compared to Propofol

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The evaluation of the presented study will work on the practicability of inhalative sedation on the ICU, potential benefits and limitations of the ACD system in a postoperative sedated patient population in comparison to a standard intravenous sedation regimen with propofol, and focus on renal and hepatic function, cardioprotection and pharmacoeconomics

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Klinikum Ludwigshafen
• Collaborator: Universitätsmedizin Mannheim
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• 18-80 years

• elective operative procedure, and indication for admission to the ICU for postoperative sedation

• ASA I-III

• weight 50-120 kg

• Haemoglobin > 10 g/dl

• ability and acceptance to agree to the study participation

Exclusion Criteria:

• malignant hyperthermia

• muscle diseases or weakness

• liver insufficiency (ASAT, ALAT > 40 U/min)

• pancreas insufficiency

• emergencies

• women in child bearing age and missing negative pregnancy test, pregnancy or lactation

• diseases from the central nervous system (such as M. Parkinson and multiple sclerosis)

• increased intracranial pressure, head trauma

• pre-existing delirium, agitation and psychiatric derangements

• alcohol and drug abuse (including opioid abuse)

• allergy to any of the study agents

• refusal from the patient to participate in the study

• participation in another study project.