The underlying bacterial colonization in lower respiratory tract (LRT) of COPD patients may
be related to acute exacerbation of COPD (AECOPD) and disease progression. However, there is
a lack of strong evidence on the effect of LRT bacterial decolonization on COPD. This study
was designed to confirm the prophylactic effect of decolonization of LRT bacteria on AECOPD
and establish a novel prophylactic therapy for sable COPD.