Inhaled Corticosteroids Versus Observation for Patients With Decreased Lung Function Status

• Status: Terminated
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical research study is to compare lung function of patients who inhale steroids in the early stages of post-transplant constrictive bronchiolitis (PTCB) to patients who continue with standard of care.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: M.D. Anderson Cancer Center
• Treatments: Fluticasone; Xhance

Criteria

Inclusion Criteria:

1. Patients >/=18 years of age.

2. Patients must be engrafted and at least 80 days post allogeneic hematopoietic stem cell transplantation.

3. New onset airflow obstruction defined as decline of forced expiratory volume in 1 second (FEV1) percent predicted >/= 15%.

4. Total Lung Capacity (TLC) > 85% to rule out restrictive lung disease.

5. Patient must be willing to comply with all study procedures and capable of signing informed consent.

Exclusion Criteria:

1. Patients with active pulmonary infection.

2. Patients with known hypersensitivity to corticosteroids