Inhaled Milrinone in Cardiac Surgery

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the concentration-effect relationship of inhaled milrinone after prophylactic administration in cardiac surgical patients with preoperative pulmonary hypertension undergoing cardiopulmonary bypass.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Montreal Heart Institute
• Collaborators: Canadian Institutes of Health Research (CIHR); Fonds de la Recherche en Santé du Québec; St. Justine's Hospital
• Treatments: Milrinone

Criteria

Inclusion Criteria:

• Patients scheduled for elective cardiac surgery under CPB

• High risk patients: NYHA class II-III

• Preoperative diagnostic of pulmonary hypertension:

• Systolic pulmonary artery pressure (sPAP) > 35 mm Hg; or

• Mean pulmonary artery pressure (mPAP) > 25 mm Hg; or

• mAP/mPAP < 3.0 (after induction of anesthesia).

Exclusion Criteria:

• Open Heart Surgery

• Contraindication to transesophageal echocardiography (TEE)

• Hemodynamic instability before surgery

• Emergency surgery