Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Status:
Terminated
Trial end date:
1998-05-01
Target enrollment:
Participant gender:
Summary
Respiratory failure in term newborns is associated with increased rates of death and
long-term neurodevelopmental problems. This large international multicenter trial randomized
newborns who had failed to respond to intensive care, including high levels of ventilator
support, to receive either inhaled nitric oxide (iNO) or 100 percent oxygen to test whether
iNO would decrease their risk of dying or requiring temporary lung bypass. Infants were
followed during their initial hospitalization; their outcome was assessed at 18 to 24 mos of
age.
Phase:
Phase 3
Details
Lead Sponsor:
NICHD Neonatal Research Network
Collaborators:
Medical Research Council of Canada National Center for Research Resources (NCRR)