Inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults (iNOCAPA)
Status:
Recruiting
Trial end date:
2026-01-31
Target enrollment:
Participant gender:
Summary
This study is a multi-center, double blind, randomized controlled trial of inhaled nitric
oxide (iNO) in children and adults with cardiac arrest (CA). The purpose of this pilot study
is to test the feasibility of rapidly randomizing patients to iNO or sham treatment during
cardiopulmonary resuscitation (CPR) or shortly after return of circulation (ROC) and evaluate
blood biomarkers associated with iNO compared to sham. Return of circulation may refer to
return of spontaneous circulation (ROSC) or ROC through extracorporeal cardiopulmonary
resuscitation (E-CPR).