Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury
Status:
Not yet recruiting
Trial end date:
2026-07-01
Target enrollment:
Participant gender:
Summary
Traumatic brain injury (TBI) causes acute deficits in cerebral perfusion which may lead to
secondary injury and worse outcomes. Inhaled nitric oxide (iNO) is a vasodilator that
increases cerebral blood flow and is clinically used for hypoxic respiratory failure in
neonates and adults. The investigators will perform a randomized controlled trial of iNO
treatment in TBI patients acutely after injury. The investigators will then assess perfusion
changes with optic neuromonitoring, blood biomarkers, and 6 month clinical outcomes.