A Prospective, Open labeled, multi-Center, Evaluation of the Efficacy Safety and Tolerability
of Nitric Oxide Given Intermittently via Inhalation to Subjects with NTM (specifically MABSC)
Nitric Oxide (NO) has been shown to play a critical role in various biological functions. In
the airways, NO is considered to play a key role in the innate immune system in which the
first-line of host defense against microbes is built.
In vitro studies suggested that NO, in part per million (ppm) concentrations, possesses
anti-microbial activity against a wide variety of phyla including fungi, and
antibiotic-resistance bacteria.
In this study the investigators wish to evaluate the efficacy, safety and tolerability of 160
ppm Nitric Oxide intermittently delivered via inhalation to subjects infected with
Non-tuberculosis mycobacteria (NTM), specifically with MABSC.