Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Cystic fibrosis (CF) lung disease is characterized by chronic bacterial colonization and
recurrent infection of the airways. Lowering the airway surface liquid (ASL) salt
concentration has been shown to increase activity of salt sensitive antimicrobial peptides.
Xylitol is a 5-carbon sugar that can lower the ASL salt concentration, thus enhancing innate
immunity.In this study, the investigators plan to study the safety and efficacy of 2 weeks of
inhaled xylitol compared to 2 weeks of hypertonic saline in a randomized crossover design in
stable subjects with cystic fibrosis
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Joseph Zabner University of Iowa
Collaborators:
Ann & Robert H Lurie Children's Hospital of Chicago Northwestern University