Inhibitory Effect of Propofol on Perineal Pruritus in Patients Undergoing Day Surgery
Status:
Completed
Trial end date:
2021-12-04
Target enrollment:
Participant gender:
Summary
OBJECTIVE: To investigate the inhibitory effect of different doses of propofol on perineal
pruritus induced by dexamethasone sodium phosphate injection in women, with a view to
providing clinical reference for comfortable clinical care in day surgery.
METHODS: One hundred and fifty patients with ASA classification I or II undergoing elective
day surgery were randomly divided into six groups of P1, P2, P3, P4, P5 and D1, with 25 cases
in each group. Before administration of dexamethasone, propofol injection 0.1 mg/kg, 0.2
mg/kg, 0.3 mg/kg, 0.4 mg/kg and 0.5 mg/kg were given intravenously in groups P1, P2, P3, P4
and P5, respectively (injection rate was 5 s), followed by 30 s of intravenous dexamethasone
sodium phosphate 10 mg in all five groups; 5 ml of saline was given in group D1, and 30 s
After that, dexamethasone sodium phosphate injection was given (injection speed was 5s in all
five groups). The perineal itching, the onset and duration of itching, the visual analogue
score (VAS) of itching, the sleep disorder sedation score (Ramsay score) and the occurrence
of adverse reactions were recorded in the five groups.