Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance

• Status: Not yet recruiting
• Trial end date: 2025-08-15
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to evaluate the effect of early albumin transfusion within massive transfusion protocol on fluid balance and reduced requirement of transfusion.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Adult patients (19 or older)

• Admitted or planned to admit surgical intensive care unit

• Patients with decreased hemoglobin level more than 20% from baseline within 12 hours, Or

• Patients who are suspected bleeding and hemodynamically unstable requiring more than 0.05mcg/kg/min of norepinephrine infusion to maintain mean blood pressure higher than 65mmHg

Exclusion Criteria:

• Contraindicated to albumin product

• patients with risk factors of increased circulatory volume (heart failure, pulmonary edema, end-stage renal disease with oliguria)

• patients with hemolytic anemia

• History of anaphylactic reaction to blood product