Injectable Collagenase For Burns' Associated Contracture

• Status: Unknown status
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

A pilot experiment to test the efficiency of the enzyme Collagenase in treating contractures which result's from burn's healing process.

So far, treatment of choice in patients with burn's created movement limiting contractures, concentrated around supportive care. Patients were referred to surgical intervention only if necessary. Treatment by injecting an external enzyme is avant-garde and hasn't been done under such conditions.

This study might introduce a new kind of treatment, which can be done in ambulatory environment .This type of treatment might significantly improve patients' function and quality of life, with no need for a surgical intervention.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sheba Medical Center

Criteria

Inclusion Criteria:

1. age - 18+

2. Contracture is 6 month old or more

3. Place of contracture in a flex-ext joint only (e.g knee, elbow)

4. Contracture leads to 15% decrease in joint range of movement vs anatomical range

5. Physiotherapy can no longer improve those patients condition

Exclusion Criteria:

1. Any systemic condition involving skin or soft tissue disease

2. skin disease related to elastin, collagen or keratinocytes

3. Known allergy to Clostridium Collagenase enzyme

4. Psychiatric, Prisoners, Soldiers, Pregnant women

5. Patients whom due to their home location will not be available to frequent surveillance