Insulin Cardioplegia for Poor Left Ventricular Function

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular function (e.g. ejection fraction <40%).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Health Network, Toronto
• Collaborator: Canadian Institutes of Health Research (CIHR)
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Patient has been referred for isolated coronary bypass surgery.

• LV grade 3 or 4, LVEF <40% by angio, echo, RNA.

Exclusion Criteria:

• Patient is undergoing reoperative surgery (i.e., has had any previous cardiac surgery)

• Surgeon has planned another procedure in addition to coronary bypass surgery (e.g., valve repair, replacement, ascending aorta repair or replacement, left ventricular aneurysm resection, repair of congenital defect, carotid surgery, repair of abdominal aortic aneurysm).

• Patient is scheduled for minimally invasive surgery.

• More recent assessment of LV function with LV grade 1 0r 2, LVEF>40%.

• 5 or 6 days post MI.