Insulin Clamp Ancillary Study for Assessment of Insulin Resistance
Status:
Completed
Trial end date:
2016-02-15
Target enrollment:
Participant gender:
Summary
Insulin Clamp Ancillary study for Assessment of Insulin Resistance will be conducted as a
sub-study to the main protocol, Metformin Therapy for Overweight Adolescents With Type 1
Diabetes (NCT01881828). The purpose of this ancillary study is to assess if metformin will
improve tissue-specific insulin resistance (IR) in type 1 diabetes using a hyperinsulinemic
euglycemic clamp; a 3-month randomized trial comparing metformin versus placebo in 12 to <20
year olds with BMI >85th percentile ( total daily insulin dose >0.7 units/kg, and HbA1c
7.0%-9.9%).