Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus
Status:
Completed
Trial end date:
2004-11-01
Target enrollment:
Participant gender:
Summary
Our investigation studies the role of acute insulin administration on the diabetic heart, its
corresponding effective blood-insulin level and the time-course applicability of insulin in a
routine clinical setting.
A case series of six male (48.1 ± 4.9 y/o) patients with controlled diabetes (HbA1c of 6.6 ±
0.3%, disease duration of 14.4 ± 6.7 yr). Each subject was evaluated for glucose homeostatic,
hemodynamic and echocardiographic systolic and diastolic parameters at baseline and following
two successive insulin-load steps of a euglycemic hyperinsulinemic clamp study, each 2 h in
duration. Results are presented as a mean ± SEM and analysed using the student's t-test.