Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes

• Status: Completed
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effects of treating insulin resistance on memory and attention, brain glucose utilization, and proteins in spinal fluid.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Nateglinide; Pioglitazone

Criteria

Inclusion Criteria:

• Impaired glucose tolerance OR mild type 2 diabetes mellitus OR normal blood sugar regulation

• Stable weight and activity level

Exclusion Criteria:

• Medications for diabetes

• Dementia

• Medications with known effects on memory

• Serious neurologic disease or head trauma

• Serious systemic illness (e.g., renal failure or uncontrolled hypertension)

• Serious psychiatric illness (e.g., schizophrenia or bipolar disorder)

• Allergy to pioglitazone or nateglinide