Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules
Status:
Completed
Trial end date:
2019-04-17
Target enrollment:
Participant gender:
Summary
It has been shown that insulin might be involved in the pathogenesis of thyroid growth.
Objective To evaluate the impact of IR and metformin use on the volume of benign thyroid
nodules (TNs).
Methods A randomized clinical trial to placebo (P) or MTF use. Previous fine needle
aspiration confirming the diagnosis is necessary to inclusion. Patients will receive similar
tablets of MTF and placebo and instruct to take 3 tablets/day of MTF (500mg/tablet). Thyroid
volume, as TN volume, will be assess by ultrasound, both in the beginning, six months and one
year after randomization, by the same researcher blinded regarding location group. Blood
samples to measure: TSH, FT4, TPO-Ab, lipid profile, glucose and insulin were done after 8h
fasting.