Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop
metabolic disorders that are similar to those observed in conditions like type 2 diabetes.
These metabolic disorders, including insulin resistance, obesity, hyperinsulinemia, and
glucose intolerance, are associated with increased BC recurrence and mortality. Skeletal
muscle is the major site of glucose uptake in humans. The aims of the present project are to
1) determine the involvement of insulin resistance in skeletal muscle in the metabolic
disorders prevalent in BC survivors, 2) identify BC-and/or treatment-induced molecular
changes in skeletal muscle from BC survivors .