Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the
kidneys in women with PCOS, but not in normal women. This leads to a reduction in circulating
DCI and insulin stimulated release of DCI-IPG.To determine if decreasing circulating insulin
directly by inhibition of islet insulin release with diazoxide in obese women with PCOS
1)decreases the renal clearance of DCI and 2) increases the circulating concentration of DCI.
Phase:
N/A
Details
Lead Sponsor:
Virginia Commonwealth University
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)