Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects

• Status: Unknown status
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate the role of transmission via the vagal nerve for the effect of glucose and Glucagon-like peptide-1 (GLP-1) in respect to insulin secretion.

The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with and without intact nervous supply.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Gentofte, Copenhagen
• Collaborator: University of Copenhagen
• Treatments: Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1

Criteria

Inclusion Criteria:

• normal fasting plasma glucose

• normal hemoglobin

• informed consent

Exclusion Criteria:

• type 1 diabetes mellitus or type 2 diabetes mellitus

• body mass index > 30

• inflammatory bowel disease

• intestinal surgery

• serum creatinine > 250 µM and/or albuminuria

• ALAT > 2 x normal value

• Severe cardiac insufficiency

• in treatment with medicine which cannot be paused for 12 hours