Integrated Pulmonary Index and Opioid Based Patient Controlled Analgesia

• Status: Completed
• Trial end date: 2018-08-01
• Target enrollment: 0
• Participant gender: All

Summary

An optimal analgesic therapy is very important for postoperative recovery. In recent years, several studies showed that the prevalence of the moderate to severe pain after craniotomy ranged from 69 to 87% of patients. The investigators showed that the use of morphine based patient controlled analgesia prevented moderate to severe postoperative pain in patients undergoing supratentorial craniotomy. Morphine related side effects such as sedation, miosis, respiratory depression, nausea and vomiting produce a general reluctance for their use in neurosurgery. Therefore, all patients were closely observed to detect opioid related side effects in the intensive care unit for 24 hours following surgery in our previous study. The Integrated Pulmonary Index (IPI) is a new tool that calculates respiratory and hemodynamic parameters noninvasively. In the present study the investigators will use different doses of morphine based patient-controlled analgesia and the IPI system to determine more effective and safer morphine dose for postoperative analgesia following supratentorial craniotomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Istanbul University
• Treatments: Acetaminophen; Dexketoprofen trometamol; Morphine

Criteria

Inclusion Criteria: , brain tumors, elective supratentorial craniotomies,

• Conscious patients

• Elective supratentorial craniotomies

• ASA I-III

Exclusion Criteria:

• Unconscious postoperatively

• Chronic pain

• Opioid, dexketoprofen or paracetamol allergy

• Delirium

• Renal insufficiency

• Alcohol, opioid dependency

• Transsphenoidal pituitary surgery