Integrated Traditional Chinese and Clinical Medicine for Chronic Hepatitis B and Its Complication
Status:
Not yet recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
Hepatic encephalopathy is the most common complication after TIPS, and hepatic encephalopathy
occurs in almost all portosystemic shunts. For patients with severe upper gastrointestinal
bleeding or refractory ascites in the decompensated chronic hepatitis B, transjugular
intrahepatic portosystemic shunt (TIPS) is a very effective treatment. However, due to the
severe complications such as hepatic encephalopathy after TIPS, the clinical application of
TIPS is limited. Literature studies have shown that the incidence of encephalopathy after
TIPS is about 35%. TIPS reduces the portal vena blood flow into the liver by establishing a
new channel. But at the same time, the toxic substances from the gastrointestinal tract and
other organs do not enter the liver to detoxify, and are more likely to enter the brain,
leading to hepatic encephalopathy.
Moreover, studies have found that the liver and the intestine originate from the same germ
layer and are closely related to each other in anatomy and function. There are a large number
of microorganisms living in the intestinal tract. Normally, the intestinal tract, as the
first defense of the human body, can effectively prevent bacteria and their products from
entering the bloodstream. In cirrhosis and portal hypertension, blood return disorder causes
intestinal damage. A series of microbes and product endotoxins such as gram-negative bacteria
will enter the blood through the injury, and the toxins in the peripheral blood will enter
the brain and cause hepatic encephalopathy happened.
The research team's early treatment plan with integrated traditional Chinese and Western
medicine proved that it greatly reduced the incidence of hepatic encephalopathy after TIPS.
And improve the clinical symptoms and signs of patients with liver cirrhosis, and improve the
quality of life and survival of patients.