Integrative Medicine of IgA Nephropathy

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study was designed to identify the efficacy and safety of Integrative Medicine by joint oral steroid medicine on liver-kidney yin deficiency, severe IgA nephropathy. Furthermore, search for potential diagnostic predictor in IgA Nephropathy by Proteomics and Metabolomics.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai University of Traditional Chinese Medicine
• Collaborators: Fudan University; RenJi Hospital; Ruijin Hospital; Shanghai 6th People's Hospital; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
• Treatments: Hormones; Prednisone

Criteria

Inclusion Criteria:

1. The primary IgAN was confirmed by renal biopsy and clinical examination, and the pathological manifestations were Lee's grade and above;

2. TCM is liver kidney yin deficiency syndrome;

3. age 18-70 years old, sex, nationality is not limited;

4. CKD phase 2-4 （89 ml/min>eGFR（EPI Formula）>15ml/min/1.73m2）;

5. 24 hour urinary protein≥1g.

Exclusion Criteria:

1. It had received immunosuppressive drugs and cytotoxic therapy within the past 3 months more than 4 weeks;

2. It had received corticosteroids (prednisone or prednisolone) within the past 3 months more than 20mg/d for more than up to 4 weeks;

3. Acute or progressive glomerulonephritis patients;

4. Severe complications threat to life, such as severe infection;

5. Active hepatitis B and liver function test sustained abnormal;

6. Patients with malignant tumor or have a history of cancer, HIV infection, history of mental illness, acute central nervous system diseases, severe gastrointestinal diseases, prohibition of the use of hormone;

7. Abnormal glucose metabolism, fasting blood glucose over 6.2mmol/L;

8. Gravid or lactation woman;

9. Other clinical trials are being studied;

10. Merger with other serious disease and dysfunction of the organ.