Intensive Statin Therapy in PCI Patient With Acute Coronary Syndrome

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Compare with regular regimen, the aim of this study is to testify whether having more statin during PCI will benefit in Chinese population, and to find out optimal dose of the drug for patient after PCI.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xijing Hospital
• Treatments: Atorvastatin; Atorvastatin Calcium; Hydroxymethylglutaryl-CoA Reductase Inhibitors

Criteria

Inclusion Criteria:

• 18-85 years old

• Patients with clinical diagnosis of ACS

• Evidence of a personally signed and dated informed consent document

Exclusion Criteria:

• Taking or, needing to take atorvastatin over than 20mg/d or any other equivalent statin in the next 6 months, or needing to take fibrates simultaneously according to investigators' judgment.

• LDL-C < 1.8mmol/L in patients without statin therapy in 1 months

• Endstage congestive heart failure, or LVEF < 30%

• Active hepatic disease or hepatic dysfunction, or AST/ALT > 1.5UNL

• Myopathy or increased creatine kinase (CK>2 UNL)

• Severe renal dysfunction(Scr > 3 mg/dl or 264μmol/L)

• Allergic or experienced serious adverse reaction to HMG-CoA reductase, or ineligible to take statin as investigator's judgment

• Severe aortic valve stenosis or severe mitral stenosis, Obstructive hypertrophic cardiomyopathy, pericardial diseases

• Pregnancy, lactation, or child bearing potential women without any effective contraception

• Accompanied with malignant disease or other disease, which cause life expectancy < 6 months

• Participating in other interventional clinical trails using drugs or devices

• Patients with any condition which, in the investigator's judgment, might increase the risk to the subject for any adverse event or abnormal laboratory finding