Overview
Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis
Status:
Unknown status
Unknown status
Trial end date:
2018-06-01
2018-06-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Purpose: Intracranial atherosclerosis is a common condition in Korean population consisting over 25% of ischemic stroke etiology. American Stroke Association and Korean Stroke Society recommend antiplatelet and statin for the treatment of intracranial atherosclerosis. Besides lowering blood cholesterol levels statin also stabilize atherosclerotic plaque and eventually lower the risk of ischemic stroke. However, little evidence resides on the effect of statin treatment on intracranial atherosclerosis. Recent advance in high-tesla magnetic resonance imaging enables direct imaging of intracranial atherosclerotic plaque and further assessment of treatment efficacy of statin in stabilization of intracranial atherosclerotic plaque became possible.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Samsung Medical CenterCollaborator:
Don-A Pharmaceutical, Seoul, South KoreaTreatments:
Atorvastatin
Atorvastatin Calcium
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Rosuvastatin Calcium
Criteria
Inclusion Criteria:- Acute ischemic stroke patients within 7 days of symptom onset
- Symptomatic intracranial artery stenosis (above 30%) at proximal portion of middle
cerebral artery (MCA), basilar artery, or intracranial portion of intracranial artery
(ICA).
- Not receiving statins (HMA-coA reductase)
- Willing and able to comply with scheduled visits, lifestyle guidelines, treatment
plan, laboratory tests, and other study procedures.
Exclusion Criteria:
- Extracranial artery (carotid artery bifurcation, proximal vertebral artery) stenosis
above 50%
- Stroke attributable to cardioembolic origin (atrial fibrillation, valvular heart
disease, aortic arch atherosclerosis)
- Severe hepatic or renal dysfunction
- Pregnant females as determined by positive urine hCG test or lactating females
- Subjects considered unwilling or unable to comply with the imaging procedures and
study visit schedule