Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

An increase in blood glucose is a common clinical symptom in patients following traumatic brain injury. Studies confirm that death after traumatic brain injury was not only associated with nerve injury, but also correlated with abnormal physiological and metabolic reactions. Hyperglycemia is a manifestation of physiological and metabolic disorders after traumatic brain injury. Traumatic brain injury induced hyperglycemia, and then aggravated secondary injury to the brain. Therefore, it is of important clinical significance to study the treatment of hyperglycemia after traumatic brain injury.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lianyungang Oriental Hospital
• Collaborator: The First People's Hospital of Lianyungang
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Severe closed traumatic brain injury diagnosed in the clinic;

• Severe closed traumatic brain injury verified by CT examinations;

• Patients who are in accordance with the indications of craniotomy for severe traumatic brain injury;

• Blood glucose levels > 7.0 mmol/L measured twice by rapid examination within 2 hours of hospital admission;

• Glasgow coma score between 3 and 8;

• At the age of 18 - 80 years old;

• Irrespective of gender.

Exclusion Criteria:

• At the age of < 18 years old or > 80 years old;

• Glasgow coma score > 8;

• Patients combined with multiple site damage;

• Hemodialysis-dependent patients combined with diabetic nephropathy;

• Patients with nervous system disease before traumatic brain injury;

• Patients with a history of diabetes before suffering from a traumatic brain injury.