Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Pantoprazole 80 mg in Healthy Subjects
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
Primary objective:
- Assess the effects of clopidogrel (300 mg loading dose followed by 4 days 75 mg/day) on
Adenosine diphosphate (ADP)-induced platelet aggregation when given concomitantly with
pantoprazole 80 mg/day compared to given alone in healthy male subjects
- Compare the pharmacokinetic profiles of clopidogrel active metabolite when clopidogrel
is given either alone or concomitantly with pantoprazole
Secondary Objective:
- Compare the pharmacokinetic profiles of clopidogrel when clopidogrel is given either
alone or concomitantly with pantoprazole