Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Recently a new model for the interaction of sevoflurane propofol and remifentanil was developed. The potency of any combination of the three drugs is defined as probability that a subject tolerates laryngoscopy without movement response. The model allows to compare the potency of intravenous and inhalation anesthetics. If the model is valid also for other stimuli than laryngoscopy and for other responses (e.g. blood pressure or heart rate increase upon stimulation). If the model is valid equipotent concentrations of sevoflurane and propofol the same remifentanil concentration would be sufficient to suppress hemodynamic response to a given stimulus. This will be investigated it the study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Anesthetics; Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• ASA physical status 1 or 2

• Written informed consent

Exclusion Criteria

• Cardiovascular disease

• Pulmonary disease

• Liver disease

• CNS disease

• Alcohol or drug abuse

• Chronic intake of CNS active drugs

• Body mass index > 35

• Diabetes mellitus

• Hypersensitivity or allergy to one of the study drugs