Interactions Between HIV Protease Inhibitors and Calcium Channel Blockers
Status:
Completed
Trial end date:
2004-04-01
Target enrollment:
Participant gender:
Summary
Diltiazem CD and amlodipine are drugs used to treat heart disease and high blood pressure.
The purpose of this study is to find out if these drugs interact with the anti-HIV drugs
indinavir and ritonavir. The study will also look at the safety of taking the study drugs
together.
Heart disease and high blood pressure are major health concerns for people with HIV. Standard
treatment for these illnesses often includes calcium channel blockers (CCBs). There is a
potential for significant drug interactions between CCBs and HIV protease inhibitors (PIs)
that may influence the dosing, monitoring, and choosing of CCBs and PIs when used in people
infected with HIV. This study will examine the drug interactions between 2 commonly used CCBs
and the PI combination indinavir and ritonavir (IDV/RTV). This information should help
doctors choose the appropriate treatment for high blood pressure or heart disease in people
taking PIs.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)