Interest of COLchicine in the Treatment of Patients With Acute Myocardial INfarction and With Inflammatory Response
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
Background:
Colchicine is an old well-known venerable drug routinely used in gout attacks for instance.
More recnetly it is regularly use in the treatment of pericarditis. It couls exert
antiiflammatory effects targeting the adverse inflammation occuring incase of acute
myocardial infarction, which is involved in poor outcomes or longer stay at hospital.
Endpoints:
- Main endpoint: AUC CRP during the initial hospital stay
- Secondary endpoints:
- Clinical: oucomes
- Imaging: ETT, MRI
- Biological: various biomarkers
Method Randomized, controled, open-labbelled, comparing two parallel arms: conventionnal
optimal treatment versus conventionnal optimal treatment + colchicine