Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children
Status:
Unknown status
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
Tuberculosis (TB) is a disease affecting the lungs that is caused by a germ spread by
coughing. TB infection is currently diagnosed by a skin test that has limited accuracy. The
purpose of this study is to look at the reliability of a new blood test for diagnosing TB
infection in children. Study participants will include 300 HIV-infected (HIV infection is a
viral infection that causes disease which destroys the body's ability to protect itself from
infection and disease.) children and 500 HIV-uninfected children, ages 3 months to 5 years,
residing in the Khayelitsha and Ravensmead/Uitsig Communities of the Western Cape Province,
South Africa. Study procedures will include questionnaires, HIV and TB testing, which will be
performed by blood and skin tests. Participants may be involved in study related procedures
for up to 24 months.
Details
Lead Sponsor:
Case Western Reserve University
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)