Intermittent Pneumatic Compression in Surgical Patients at Extremely-high Risk for Venous Thromboembolism

• Status: Completed
• Trial end date: 2018-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to evaluate efficacy and safety of venous thromboembolism prophylaxis by the combination of graduated compression stockings (GCS), standard doses of low-molecular-weight heparins (LMWH) and sequential compression device (SCD) in the mixed group of surgical patients at high and extremely high risk for venous thromboembolism.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pirogov Russian National Research Medical University
• Collaborator: Medtronic

Criteria

Inclusion Criteria:

• Age over 40

• Major surgery undergone*

• High risk of postoperative VTE according to a National guideline**

• 11+ Caprini scores

• Informed consent is given

Exclusion Criteria:

• Acute deep vein thrombosis (DVT) at baseline

• Performed inferior vena cava (IVC) plication or implanted IVC filter

• Regular preoperative anticoagulation

• Postoperative anticoagulation needed at therapeutic doses

• Absence of anticoagulation for more than 5 days after surgery

• Coagulopathy (not related to Disseminated intravascular coagulation syndrome)

• Thrombocytopenia

• Hemorrhagic diathesis

• Lower limb soft tissue infection

• Ankle-brachial index < 0.6

• Major surgery - intervention under endotracheal anesthesia with duration of more than 60 min.

• In accordance with a standard stratification system, high risk of VTE group includes patients over 60 years old after major surgery and patients 40-60 years old with additional risk factors after major surgery.