Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia
Status:
Completed
Trial end date:
2004-10-01
Target enrollment:
Participant gender:
Summary
Prevention of malaria in pregnancy is critical given the high incidence of malaria in Zambia
and its serious impact on both maternal and infant survival. Intermittent presumptive
treatment with sulfadoxine-pyrimethamine has been shown to be highly efficacious for reducing
the risk of malaria in pregnancy. However, based on a study done in western Kenya,
HIV-infected pregnant women may need more frequent dosing of SP, i.e., on a monthly basis
rather than the standard 2-dose regimen given during the second and third trimesters, as HIV
appears to reduce the effectiveness of the SP drug combination. The goal of this study was to
evaluate the efficacy of the standard dosing regimen in comparison to an intensive monthly SP
dosing schedule in HIV-positive women.
Phase:
Phase 4
Details
Lead Sponsor:
Center for International Health and Development
Collaborator:
Centers for Disease Control and Prevention
Treatments:
Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine