Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet

• Status: Completed
• Trial end date: 2006-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension occurs when this balance is altered or abnormal. We hypothesized that this balance is influenced by salt intake: therefore dietary salt affects the natriuretic response to the renal dopaminergic agonist Fenoldopam, and the Angiotensin Converting Enzyme inhibitor, Enalapril.

In this trial we study normal salt balance mechanisms in salt resistant adults with normal blood pressure.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Georgetown University
• Collaborator: University of Virginia
• Treatments: Enalapril; Enalaprilat; Fenoldopam

Criteria

Inclusion Criteria:

• Volunteers

• Healthy

• Normal Blood Pressure

Exclusion Criteria:

• Renal Impairment

• Obesity

• Salt sensitive increase in blood pressure