Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
Studies with intestinally asymptomatic patients with spondyloarthritis showed that
approximately 1/3 had visible ulcers in the colon by scopic examinations and 2/3 had changes
detectable by microscopy. Only those patients who improved in arthritis symptoms showed
improvement in colonic changes. In these studies only colon and the terminal ileum was
examined. Inflammation of the small intestine was not examined. Newer studies have shown an
immunological link between Crohns disease and spondyloarthritis but not ulcerative colitis.
The investigators wish to examine the small intestine in these patients before and after
treatment, since they expect to find ulcers there linking spondyloarthritis to Crohns disease
and healing after treatment.
Phase:
Phase 4
Details
Lead Sponsor:
Regionshospitalet Silkeborg
Collaborators:
Abbott Central Denmark Region Given Imaging Ltd. Medtronic - MITG