Intra-Articular Dexamethasone to Prevent Post-Traumatic Osteoarthritis: A Pilot Study

• Status: Completed
• Trial end date: 2019-07-19
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of the study is to see if a single wrist injection (intra-articular) of dexamethasone at the time of treatment will reduce the incidence of early-onset of post traumatic osteoarthritis.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

1. Unstable distal radius fracture

2. Fracture type AO B1, B2, B3, C1, C2 or C3.

3. 18-65 years old

4. Understand and read English

5. Community dwelling (not in assisted living or NH)

Exclusion criteria:

1. Open or bilateral DRF

2. Associated upper extremity carpal fracture or carpal ligament injuries requiring casting or surgical repair at the time of DRF fixation.

3. Greater than 2 weeks post injury

4. Neurologic disorders affecting the hand, wrist or arm.

5. History of permanent dementia, Alzheimer's or other neurologic dx

6. Substance abuse

7. Pathologic fractures

8. Known pregnancy

9. Radiocarpal joint arthritis