Intra Articular Injection of Microfat and PRP in Knee Osteoarthritis

• Status: Completed
• Trial end date: 2020-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis of this project is that the injection of an innovative treatment (microfat and dose of autologous PRP) allows to delay knee arthroplasty in patients with knee OA resistant to medical treatment.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Clinique Juge

Criteria

Inclusion Criteria:

• Males and females between 20 to 65 years of age

• Symptomatic knee osteoarthritis , ICRS grade 2, 3 ou 4 with VAS > 4 and failure of medical treatment for at least one year

• BMI between 20 to 30

• Written informed consent, signed by patient or legal representative

• HB > 10g/dl

• Negative pregnancy test

• Social security affiliated

Exclusion Criteria:

• IRM contre-indications: ocular loose bodies, pace maker, neurostimulateur, cochlear implant, vascular clips, mettalic cardiac valve

• BMI < 20

• Thrombocytopenia < 150 G/L

• Thrombocytosis > 450 G/L

• Thrombopathy

• TP < 70%

• TCA patient / witness rapport > 1,20

• Anaemia: HB < 10g/dl

• Positive serology VIH1 and 2, Agp24, Ac HCV, Ag HbS, AcHbc, Ac HTLV I and II, TPHA

• Treatment by platelet inhibiting agent, aspirin, anti vitamin K completed more than 2 weeks before inclusion

• Chronic treatment by corticosteroid per os or treatment completed more than 2 weeks before inclusion

• Intra articular knee injection of corticosteroid more than 8 weeks before inclusion

• Intra articular knee injection of hyaluronic acid more than 8 weeks before inclusion

• NSAI treatment completed more than 2 weeks before inclusion

• Fever or recent disease

• Auto immune disease

• Inflammatory Arthritis

• Immune deficit

• Infectious disease

• Malignant tumor being treated or history of malignant tumor