Intra-Renal Therapy of Diuretic Unresponsive Acute Kidney Injury
Status:
Withdrawn
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
Randomized prospective trial of patients with diuretic unresponsive acute kidney injury where
patients will receive standard supportive therapy with diuretics versus intra-renal delivery
of the vasodilator fenoldopam mesylate.
Patients with rising creatinine who fail to respond to bolus diuretics will be treated with a
prolonged course of diuretics or undergo placement of a catheter within the renal arteries
that allows for infusion of fenoldopam mesylate. The rational is that early delivery of a
high dose vasodilator may reverse the decline of renal function in patients with severe acute
kidney injury.