Intra-arterial Chemotherapy for the Treatment of Progressive Diffuse Intrinsic Pontine Gliomas (DIPG).
Status:
Completed
Trial end date:
2018-11-26
Target enrollment:
Participant gender:
Summary
The goal of this pilot study is to determine if intra-arterial (IA) chemotherapy is safe in
the treatment of progressive diffuse intrinsic pontine gliomas (DIPG). IA administration of
the chemotherapeutic agent enhances the regional distribution of the drug, thereby increasing
the local delivered dose while minimizing systemic toxicity. It also provides a treatment
option for these patients at the time of tumor recurrence.
Phase:
Phase 1
Details
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins