Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT)

• Status: Active, not recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who missed recanalization operation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hui-Sheng Chen
• Treatments: Neuroprotective Agents

Criteria

Inclusion Criteria:

1. Age ≥18 years;

2. Major neurologic deficits: 6≤NIHSS≤20;

3. Missing recanalization therapy (IVT or EVT) or progressive stroke, which was defined as symptoms worsen in 48 hours (an increase in NIHSS more than 4);

4. Premorbid mRS 0 or 1;

5. Signed informed consent.

Exclusion Criteria:

1. Modified Rankin Score >2 caused by a history of prior stroke;

2. Patients who underwent intravenous thrombolysis or Endovascular treatment;

3. Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ <80000/mm3;

4. Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;

5. Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg);

6. Unsuitable for this clinical studies assessed by researcher.