Intra-articular Hyaluronic Acid in Mild to Moderate Knee Osteoarthritis
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Objective:
To assess the impact of intraarticular hyaluronic acid (HA) on clinical outcome and on
volumetric and T2 relaxation based changes of articular cartilage in mild to moderate
osteoarthritis (OA) of the knee joint.
Methods:
Patients with moderate OA of the knee [Kellgren-Lawrence II] were recruited for a 6-months
prospective, randomized clinical trial evaluating the effect of HA on articular cartilage
morphology and composition. Clinical examinations and MRI were performed at baseline, and
after 6, 12 and 24 weeks. Cartilage volume, thickness and surface area were determined in
cartilage plates and subregions were defined using proprietary software. MRI was performed on
a 1.5 Tesla scanner; morphological evaluation was performed using 3D T1-w FLASH
Waterexcitation (WE) sequences and T2 maps were calculated from a multiecho, spin-echo
sequence.