Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Knee osteoarthritis is a very common pathology, characterized by pain, stiffness and
functional deficit. The various therapeutic options used include anti-inflammatory drug
treatment, physiokinesitherapy, minimally invasive procedures and, finally, in non-responsive
cases, surgical treatment. To date, several studies have been conducted on the
intra-articular use of oxygen-ozone in knee osteoarthritis and its potential therapeutic
benefits. However, the methodological quality of the RCTs available in the literature is not
satisfactory, so it is necessary to define a standardized protocol for therapy and
procedures. The aim of this study will be to develop a rigorous protocol to evaluate the
effectiveness of intra-articular oxygen-ozone therapy (OOT) in knee osteoarthritis and
compare it with injection therapy with hyaluronic acid (HA), currently widely used in the
treatment of knee osteoarthritis.