Intra-articular Platelet Rich Plasma vs Corticosteroid in Treatment of Knee Osteoarthritis Patients
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Knee osteoarthritis is the most common type of osteoarthritis in the lower extremity and
constitutes 23% of all arthritis cases, about 13% of females and 10% of males aged above 60
years have symptomatic knee OA. Intra-articular corticosteroids (IACs) are a frequently-used
treatment regimen for pain relief from symptomatic knee OA as it inhibits inflammation and
reduces prostaglandin synthesis. Platelet-rich plasma (PRP) is an autologous blood product
containing a high percentage of various growth factors (GFs), such as fibroblast growth
factor, epidermal growth factor, vascular endothelial growth factor, transforming growth
factor-β and platelet-derived growth factor. The aim of this study is to compare effect of
intra-articular injection of platelet rich plasma versus corticosteroid in treatment of
primary knee osteoarthritis.