Intra-articular Versus Intravenous Dexmedetomidine in Arthroscopic Knee Surgeries Under Local Anesthesia

• Status: Completed
• Trial end date: 2016-05-30
• Target enrollment: 0
• Participant gender: All

Summary

The present study will be carried to evaluate the efficacy of intra-articular 0.5 bupivacaine with intra-articular or intravenous alpha-2agonist; Dexmedetomidine; for intraoperative anesthesia and postoperative analgesia after arthroscopic knee surgery.

Arthroscopic knee surgery is one of the most common minimally invasive orthopedic procedures in recent practice which is frequently performed as a day surgery procedures. It can be done under general, regional or local anesthesia (LA) with or without sedation. It is associated with varying amount of postoperative pain. Postoperative pain negatively influences patient's early ambulation, rehabilitation and psychology which consecutively prolonged the hospital stay.

Intra-articular administration of local anesthetic for knee arthroscopy is a well-documented procedure that offers many advantages over other anesthesia types. Many anesthesiologists are still trying to improve the technique of local anesthetic administration through using many combinations with LA solutions in order to administer safe anesthesia to those patients and to obtain a pain-free knee with good operating conditions.

Dexmedetomidine is a highly selective α2 adrenergic agonist. It has analgesic, sedative, anxiolytic, hypnotic, sympatholytic, antihypertensive properties with anesthetic sparing effects. It becomes an attractive alternative to the current opioids because it does not have a respiratory depressant or addictive effect.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Anesthetics; Bupivacaine; Dexmedetomidine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status I or II

• Patients scheduled for elective unilateral knee arthroscopy

Exclusion Criteria:

• Refusal of local anesthesia

• History of cardiovascular disease

• History of cerebrovascular disease

• History of respiratory diseases

• History of impaired renal functions

• History of impaired hepatic functions

• Pregnancy

• Allergy to the study drugs

• Uncontrolled diabetes

• Coagulopathies

• Hypertension treated with α methyldopa, clonidine or β adrenergic blockers

• Patients receiving chronic pain treatment

• Patients receiving psychoactive drugs

• Patients receiving anticoagulant drugs

• Prior ipsilateral knee surgery

• Infection at site of injection