Intraarterial Nitroglycerin Versus Nicardipine and Radial Artery Occlusion
Status:
Completed
Trial end date:
2019-05-22
Target enrollment:
Participant gender:
Summary
A total of 600 patients undergoing coronary procedures via transradial access using 6F sheath
were randomized at the end of the procedure to receive either 250-µg nicardipine or 500-µg
nitroglycerin administered to the radial artery through the radial sheath before sheath
removal. A continuous patent hemostasis was applied in each patient with the use of an
oximetry to maintain an oxygen saturation of >95%, measured in the finger of the accessed arm
until compression device was totally removed. The primary outcome is early RAO which was
evaluated by color duplex ultrasonography of the accessed arteries at the day after the
radial procedure. Secondary outcome was the change of blood pressure at 2-3 minutes after
drug administration. Radial artery angiogram was performed after radial sheath insertion and
doppler ultrasound of the accesed radial artery was examined at the day after the procedure.